Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 16, 2025

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.2K

Multichannel Intraluminal Impedance and pH Monitoring: A Step Towards Pediatric Reference Values.

Francesco Cresi1, Elena Andrea Cester1, Silvia Salvatore2

  • 1Neonatology and Neonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.

Journal of Neurogastroenterology and Motility
|July 2, 2020
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of Tramadol in Pain Management of Neonates with Epidermolysis Bullosa: A Single-Center Experience.

Children (Basel, Switzerland)·2026
Same author

Toward harmonized guidelines: A systematic review of celiac disease recommendations for children with Down syndrome.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Clinical trial: Efficacy of a Low FODMAP Diet in Paediatric Irritable Bowel Syndrome-A Randomised Crossover Trial With Exploratory Metabolomic Analysis.

Alimentary pharmacology & therapeutics·2026
Same author

Juvenile polyposis in a SMAD4-mutated child: A call for early surveillance.

JPGN reports·2026
Same author

From evidence to advice: How uncertainty shapes probiotic guidance in pediatric irritable bowel syndrome.

Journal of pediatric gastroenterology and nutrition·2026
Same author

New Perspectives in Nutritional Management for Neonatal Health.

Nutrients·2026
Same journal

Substrate-dependent Differences of Colonic Hydrogen Production in a Patient With Fructose Malabsorption.

Journal of neurogastroenterology and motility·2026
Same journal

Resolution of Refractory Gastroparesis Symptoms Following Benzodiazepine Treatment for Catatonic Depression.

Journal of neurogastroenterology and motility·2026
Same journal

Clinical Outcomes of Endoscopic Radiofrequency Stretta Therapy for Gastroesophageal Reflux Disease Treatment: A Retrospective Analysis From 2 Tertiary Centers in Korea.

Journal of neurogastroenterology and motility·2026
Same journal

Patients' Knowledge, Attitudes, and Practices Regarding Non-pharmacological Treatments for Irritable Bowel Syndrome.

Journal of neurogastroenterology and motility·2026
Same journal

Real‑world Application of the International Anorectal Physiology Working Group Standardized Protocol and London Classification: A Multi‑country Cross‑sectional Survey of Anorectal Manometry Practice in Asia.

Journal of neurogastroenterology and motility·2026
Same journal

Belching and Reflux: The Relationship and the Underlying Mechanism.

Journal of neurogastroenterology and motility·2026
See all related articles
This summary is machine-generated.

This study establishes reference values for multichannel intraluminal impedance and pH monitoring (MII/pH) in children, aiding accurate diagnosis of gastroesophageal reflux (GER). Findings correlate reflux events with age, improving pediatric GER disease assessment.

Area of Science:

  • Pediatric Gastroenterology
  • Diagnostic Technology
  • Reflux Monitoring

Background:

  • Multichannel intraluminal impedance and pH monitoring (MII/pH) is the gold standard for detecting gastroesophageal reflux (GER).
  • Current MII/pH use is limited by a lack of established reference values for pediatric populations.
  • Accurate GER diagnosis in children requires age- and condition-specific normative data.

Purpose of the Study:

  • To establish reference values for MII/pH monitoring in a pediatric cohort.
  • To investigate the correlation between MII/pH parameters, age, and meal status (postprandial/fasting).
  • To provide normative data for improved diagnosis of pediatric GER disease.

Main Methods:

  • Evaluation of MII/pH traces from 195 pediatric patients (newborns, infants, children) across three Italian hospitals.
Keywords:
ChildEsophageal pH monitoringGastroesophageal refluxInfantReference values

More Related Videos

In vitro Monitoring of Extracellular pH in Real-Time
10:11

In vitro Monitoring of Extracellular pH in Real-Time

Published on: June 3, 2021

2.0K
Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection
08:24

Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

Published on: July 5, 2024

989

Related Experiment Videos

Last Updated: Dec 16, 2025

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.2K
In vitro Monitoring of Extracellular pH in Real-Time
10:11

In vitro Monitoring of Extracellular pH in Real-Time

Published on: June 3, 2021

2.0K
Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection
08:24

Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

Published on: July 5, 2024

989
  • Exclusion of patients with significant symptom-reflux associations or pathological reflux index.
  • Analysis of MII/pH data in entirety, and separately for postprandial and fasting periods.

    • Main Results:

    • Age positively correlated with acidic GER events (r=0.37, P<0.05).
    • Age negatively associated with weakly acidic GER events (r=0.46, P<0.05).
    • Established distributions of MII/pH values for a pediatric population with normal GER exposure.

    Conclusions:

    • The study provides reference MII/pH values for pediatric GER assessment.
    • These values can enhance the accuracy of GER disease diagnosis in children.
    • Normative data supports better clinical interpretation of MII/pH findings in pediatric patients.