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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

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Relationship between Lipoprotein (a) and cognitive function - Results from the Berlin Aging Study II.

Franziska Röhr¹, Nina Bucholtz¹, Sarah Toepfer¹

¹Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, 10117, Berlin, Germany.

Scientific Reports

|July 2, 2020

Summary

Low Lipoprotein (a) [Lp(a)] levels may be linked to better cognitive function in men, specifically in executive functions and processing speed. This study explored Lp(a) and cognitive aging in older adults.

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Published on: October 12, 2017

Area of Science:

Gerontology
Neuroscience
Cardiovascular Science

Background:

Age-related cognitive decline may be linked to atherosclerosis and altered lipid profiles.
Lipoprotein (a) [Lp(a)]'s role in healthy cognitive aging requires further investigation.

Purpose of the Study:

To examine the association between Lipoprotein (a) [Lp(a)] levels and cognitive performance in older adults.
To investigate potential sex differences in the relationship between Lp(a) and cognitive aging.

Main Methods:

Cross-sectional analysis of 1,380 participants (aged ≥60 years) from the Berlin Aging Study II (BASE-II).
Utilized the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-Plus test battery for cognitive domain assessment.
Employed regression models, adjusting for APOE genotype, lipids, and other risk factors.

Main Results:

Men in the lowest Lp(a) quintile demonstrated enhanced cognitive performance in executive functions and processing speed (p=0.027).
No significant associations were found in women.
The observed associations were considered weak despite differentiated cognitive assessment.

Conclusions:

Findings suggest a potential link between lower Lp(a) concentrations and better cognitive performance in older men.
Further research is needed to confirm the association and its clinical significance in cognitive aging.