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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Ascorbate maintains a low plasma oxygen level.

Louise Injarabian1,2, Marc Scherlinger3, Anne Devin2

  • 1Université de Strasbourg, CNRS, Architecture Et Réactivité de L'ARN, UPR9002, 67000, Strasbourg, France.

Scientific Reports
|July 2, 2020
PubMed
Summary
This summary is machine-generated.

Human plasma has a low oxygen level (8.4 mmHg), maintained by ascorbate-dependent oxygen reduction. This finding impacts understanding leukocyte biology and blood product storage.

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Area of Science:

  • Biochemistry
  • Physiology
  • Hematology

Background:

  • Oxygen transport in human blood is primarily mediated by red blood cells.
  • The dissolved oxygen level in plasma has not been previously quantified.
  • Plasma's oxygen solubility was assumed to be similar to that of water.

Purpose of the Study:

  • To quantify the dissolved oxygen level in human plasma.
  • To investigate the mechanisms regulating oxygen levels in plasma.
  • To explore the implications of plasma oxygen levels for cellular biology and blood product efficacy.

Main Methods:

  • Development of dedicated methods and tools for plasma pO2 measurement.
  • Experimental oxygenation of plasma to assess oxygen consumption.
  • Measurement of ascorbate levels in fresh and oxidized plasma.
  • In vivo studies in guinea pigs with varying ascorbate levels.

Main Results:

  • Human plasma exhibits a low partial pressure of oxygen (pO2) of 8.4 mmHg (1.1% O2).
  • Plasma demonstrates an ascorbate-dependent oxygen-reduction activity, distinct from simple oxygen solubility.
  • Plasma oxygenation significantly depletes ascorbate, an effect reversed by supplementation.
  • In vivo, ascorbate-deficient guinea pigs show higher plasma pO2 compared to controls.
  • Low plasma oxygen levels preserve oxidation-sensitive molecules like ubiquinol.
  • Leukocytes are adapted to low oxygen environments due to limited mitochondrial networks.

Conclusions:

  • Human plasma maintains a unique, low-oxygen environment regulated by ascorbate.
  • This low oxygen state is crucial for preserving the integrity of oxidation-sensitive components and influences leukocyte biology.
  • Understanding plasma oxygen dynamics can inform strategies for improving blood product storage and transfusion efficacy.