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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Dec 16, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Surgical Options for Optic Disc Pit Maculopathy: Perspectives and Controversies.

Salvador Pastor-Idoate1,2,3, Claudia García-Arumí Fusté4,5, Luis García-Onrubia1

  • 1IOBA Eye Institute, University of Valladolid, Valladolid, Spain.

Clinical Ophthalmology (Auckland, N.Z.)
|July 2, 2020
PubMed
Summary

Optic disc pit maculopathy causes vision loss. Surgical interventions filling the optic disc pit show promise, but more research is needed for optimal treatment strategies.

Keywords:
optic disc pitoptic disc pit maculopathyoptic disc pit maculopathy treatmentsoptic nerve stuffingpars plana vitrectomypost-operative outcomes

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Congenital Abnormalities

Background:

  • Optic disc pit (ODP) is a rare congenital optic nerve head abnormality.
  • ODP can lead to ODP-maculopathy, characterized by intraretinal and subretinal fluid, causing progressive visual loss.
  • The fluid source in ODP-maculopathy is unclear, with hypotheses including vitreous or cerebrospinal fluid.

Purpose of the Study:

  • To review and analyze surgical treatment modalities for ODP-maculopathy.
  • To identify the most effective surgical options for managing ODP-maculopathy.
  • To address the challenge of treatment comparison due to the rarity of the condition.

Main Methods:

  • Mini-review of existing literature on surgical treatments for ODP-maculopathy.
  • Analysis of reported outcomes for various surgical procedures.
  • Comparison of different surgical techniques and adjuvant therapies.

Main Results:

  • Spontaneous resolution of ODP-maculopathy is uncommon.
  • Untreated ODP-maculopathy often results in severe visual impairment (worse than 20/200).
  • Surgical procedures involving filling the ODP with self-sealing materials combined with pars plana vitrectomy have shown effectiveness.

Conclusions:

  • Optimal treatment for ODP-maculopathy remains challenging due to limited comparative data.
  • Surgical intervention, particularly ODP filling with vitrectomy, appears to be a promising approach.
  • Further research and larger case series are needed to establish a consensus on the best surgical management.