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Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The
Rusitanmujiang Maimaitiaili1, Jiadela Teliewubai1, Song Zhao1
1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Insights
Vascular aging, including arteriosclerosis and micro-albuminuria, is linked to abnormal left ventricular geometry in older Chinese adults. Early assessment of vascular aging is crucial for predicting cardiovascular events.
Area of Science:
- Cardiology
- Gerontology
- Vascular Medicine
Background:
- Few studies explore vascular aging and left ventricular (LV) geometry.
- The link between diverse vascular aging markers and abnormal LV geometry needs systematic analysis.
Purpose of the Study:
- To investigate the association between vascular aging and LV geometry.
- To analyze how different types of vascular aging relate to LV geometry changes.
Main Methods:
- 3363 older Chinese adults from the Northern Shanghai Study were analyzed.
- Vascular aging was assessed via arteriosclerosis, peripheral atherosclerosis, micro-albuminuria, and decreased eGFR.
- LV geometry included concentric remodeling, eccentric LV hypertrophy, and concentric LVH.
Main Results:
- Arteriosclerosis, micro-albuminuria, and peripheral atherosclerosis were associated with LV geometry changes (P<0.045).
- Peripheral atherosclerosis showed a strong link to LV concentric geometry (P<0.012) after adjusting for covariates.
- No significant associations were found with decreased eGFR, abnormal cIMT, or carotid plaque.
Conclusions:
- Vascular aging markers are independently associated with LV concentric geometry in older Chinese adults.
- Vascular aging assessment is important for early detection of abnormal LV geometry.
- This highlights the role of vascular aging in predicting cardiovascular events.
Purpose:
There have been few recent studies regarding vascular aging and its relationship with left ventricular (LV) geometry. Moreover, the association of abnormal LV geometry with various kinds of vascular aging has not yet been systematically analyzed. Thus, this study aimed to further elucidate this relationship.
Materials And Methods:
In this study, 3363 older participants (43.6% male, aged 71.1±5.9 years; 56.4% female, aged 71.1±6.1 years) derived from the Northern Shanghai Study were enrolled. Vascular aging criteria included arteriosclerosis, defined as carotid-femoral pulse wave velocity >10 m/s or brachial-ankle pulse wave velocity >1800 cm/s, and peripheral atherosclerosis, defined as ankle-brachial index <0.9, carotid artery intima-media thickness (cIMT) greater than 0.9 mm, or carotid plaque indicating carotid artery abnormality. Micro-albuminuria was defined as urinary albumin-to-creatinine ratio >30 mg/g. Decreased estimated glomerular filtration rate (eGFR) was defined as eGFR <60 mL/min/1.73 m2.
Results:
When vascular aging parameters were respectively adjusted for age and sex, arteriosclerosis, micro-albuminuria, and peripheral atherosclerosis were significantly associated with concentric remodeling, eccentric LV hypertrophy (LVH), and concentric LVH (P<0.045) but not with decreased eGFR or abnormal cIMT and presence of plaque. Peripheral atherosclerosis was strongly associated with LV concentric geometry (LVCG) when considering other covariates (risk factors, diseases, and treatments) (P<0.012).
Conclusion:
Vascular aging parameters such as arteriosclerosis, micro-albuminuria, and peripheral atherosclerosis are significantly and independently associated with LVCG in community-dwelling older Chinese population, suggesting the importance of vascular aging during early clinical assessment of abnormal LV geometry change and serious cardiovascular events.
