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Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review
Saeid Maghsoudi1, Bahareh Taghavi Shahraki1, Navid Rabiee2
1Department of Medicinal Chemistry, Shiraz University of Technology, Shiraz, Iran.
International Journal of Nanomedicine
|July 2, 2020
Summary
Controlled drug delivery systems (CDDSs) utilize natural and synthetic nano biopolymer blends for enhanced drug release. This review highlights their properties and applications in medicine and tissue engineering.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmacology
Background:
- Controlled drug delivery systems (CDDSs) are advancing beyond conventional methods.
- Nano polymer blends offer superior biocompatibility, biodegradability, and controlled release properties.
- Natural polymers (chitosan, starch, cellulose) and synthetic polymers (PLGA, PLA, PGA) are key components.
Purpose of the Study:
- To review CDDSs utilizing natural and synthetic nano biopolymer blends.
- To highlight the properties and applications of these blended polymers.
- To compare different nano blending systems for sustained and controlled drug release.
Main Methods:
- Literature review focusing on nano biopolymer blends for CDDSs.
- Analysis of properties like biocompatibility and biodegradability.
- Comparison of drug release profiles from various blended systems.
Main Results:
- Nano biopolymer blends demonstrate significant potential for controlled and sustained drug release.
- These blends show promise in diverse applications including drug/gene delivery, wound dressings, and tissue engineering.
- The review provides a comparative analysis of different nano blending strategies.
Conclusions:
- Nano biopolymer blends represent a significant advancement in CDDSs.
- Their unique properties facilitate improved therapeutic outcomes and broader biomedical applications.
- This review offers valuable insights into the comparative performance of various nano blending systems.
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