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Impact of Expression and Genetic Variation of microRNA-34b/c on Cognitive Dysfunction in Patients with Major

Ning Sun1,2, Chunxia Yang1, Xiaoting He1,3

  • 1Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.

Neuropsychiatric Disease and Treatment
|July 2, 2020
PubMed
Abstract

Insights

Lower miR-34c expression correlates with cognitive deficits in major depressive disorder (MDD). The rs2187473 polymorphism may be a genetic risk factor for cognitive dysfunction in MDD patients.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Major depressive disorder (MDD) is associated with cognitive impairments.
  • MicroRNAs (miRNAs) play a role in the etiology of MDD.
  • Genetic factors influence cognitive dysfunction in MDD.

Purpose of the Study:

  • To investigate the impact of miR-34b/c expression and genetic variation on cognitive dysfunction in MDD.
  • To analyze the relationship between miR-34c-5p levels and cognitive performance.
  • To assess the association of MIR34B/C gene polymorphisms with cognitive function in MDD patients.

Main Methods:

  • qRT-PCR was used to measure miR-34c-5p expression in MDD patients and controls.
  • Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Trail Making Test (TMT).
  • Genetic association analysis of MIR34B/C single-nucleotide polymorphism (SNP) loci was performed.

Main Results:

  • miR-34c-5p expression negatively correlated with language and delayed memory scores in MDD.
  • Higher miR-34c-5p levels correlated with longer completion times for TMT A and B.
  • The rs2187473 genotype showed significant interaction with MDD for immediate and delayed memory, with the CC genotype associated with better performance.

Conclusions:

  • Altered miR-34c expression significantly impacts cognitive function in MDD.
  • The miR-34b/c polymorphism rs2187473 is a potential genetic risk factor for cognitive impairment in MDD.
  • These findings may have clinical implications for managing cognitive dysfunction in MDD.
Keywords:
MDDcognitive functionmajor depressive disordermicroRNA-34csingle-nucleotide polymorphism

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