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Related Experiment Videos

Urokinase in gastrointestinal tract bleeding.

D J Glickerman1, K V Kowdley, J Rosch

  • 1Department of Diagnostic Radiology, Oregon Health Sciences University, Portland 97201.

Radiology
|August 1, 1988
PubMed
Summary

Selective urokinase infusion accurately identified small bowel bleeding in a patient with recurrent gastrointestinal bleeding. This diagnostic approach is valuable when the need for diagnosis outweighs bleeding reactivation risks.

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Area of Science:

  • Gastroenterology
  • Interventional Radiology
  • Vascular Medicine

Background:

  • Recurrent lower gastrointestinal bleeding presents diagnostic challenges.
  • Standard angiography can yield negative findings despite active bleeding.
  • Previous surgical interventions may not resolve the bleeding source.

Observation:

  • A patient with persistent gastrointestinal bleeding underwent selective urokinase infusion.
  • The infusion targeted the superior mesenteric artery.
  • Four prior angiograms had been inconclusive.

Findings:

  • Selective urokinase infusion successfully pinpointed the site of small bowel bleeding.
  • This interventional technique provided accurate diagnostic information.
  • Fibrinolytic agents can be effective in specific diagnostic scenarios.

Implications:

  • Selective urokinase infusion offers a valuable tool for diagnosing obscure gastrointestinal bleeding.
  • This method is particularly useful when conventional diagnostics fail.
  • Risk-benefit assessment is crucial when considering fibrinolytic agents for diagnosis.

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