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Updated: Dec 16, 2025

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TDO Promotes Hepatocellular Carcinoma Progression.

Shanbao Li1,2, Lei Li1, Junyi Wu1

  • 1Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.

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|July 2, 2020
PubMed
Summary
This summary is machine-generated.

Tryptophan 2,3-dioxygenase (TDO) is overexpressed in liver cancer (HCC) and promotes tumor growth and spread. TDO may serve as a new biomarker for predicting patient outcomes in HCC.

Keywords:
3-dioxygenaseTDOhepatocellular carcinomatryptophantryptophan 2

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Area of Science:

  • Biochemistry
  • Oncology

Background:

  • Tryptophan 2,3-dioxygenase (TDO) catalyzes a key step in tryptophan degradation.
  • TDO is increasingly found in human tumors, particularly hepatocellular carcinoma (HCC).

Purpose of the Study:

  • To investigate the role of TDO in hepatocellular carcinoma (HCC).

Main Methods:

  • Assessed TDO expression in HCC tissues.
  • Correlated TDO levels with clinicopathological features and patient survival.
  • Evaluated the impact of TDO on HCC cell growth, invasion, and migration in vitro and in vivo.

Main Results:

  • TDO was overexpressed in HCC tissues and linked to aggressive tumor characteristics.
  • Higher TDO expression correlated with poorer patient survival.
  • TDO overexpression enhanced HCC cell proliferation, invasion, and migration.

Conclusions:

  • TDO positively regulates HCC proliferation and invasion.
  • TDO shows potential as a novel prognostic biomarker for HCC.