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Related Concept Videos

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study.

Balasingam Vicknasingam1, Weng Tink Chooi2, Azlan Abdul Rahim1

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Kratom significantly increased pain tolerance in a controlled study, doubling the time participants could withstand cold pain. This research highlights kratom

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Area of Science:

  • Pharmacology
  • Human Physiology
  • Pain Management

Background:

  • Kratom (Mitragyna speciosa) has a history of traditional use in Southeast Asia.
  • Kratom consumption is reported globally, with pain relief being a common self-reported effect.
  • Controlled human studies on kratom's analgesic properties are limited.

Purpose of the Study:

  • To evaluate the effects of kratom on pain tolerance in humans.
  • To assess the safety and withdrawal symptoms associated with kratom use.
  • To provide objective data on kratom's potential as a pain-relieving agent.

Main Methods:

  • A randomized, placebo-controlled, double-blind study design was employed.
  • Participants received kratom or placebo decoctions.
  • Pain tolerance was measured using the cold pressor task (CPT).

Main Results:

  • Kratom ingestion significantly increased pain tolerance by over 100% compared to baseline.
  • Placebo consumption did not alter pain tolerance.
  • No significant discomfort or withdrawal symptoms were observed during the study period.

Conclusions:

  • Kratom decoction demonstrated a significant and substantial increase in pain tolerance.
  • Further research is warranted to explore kratom's pain-relieving efficacy and safety profile.
  • Objective evidence supports kratom's potential analgesic effects, meriting continued investigation.