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Related Concept Videos

Clinical Trials01:16

Clinical Trials

10.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.1K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.4K
Preclinical Development: Overview01:28

Preclinical Development: Overview

5.6K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.6K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

746
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
746
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

316
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
316

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Updated: Dec 16, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

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COVID-19 Clinical Research.

Jeffrey Chi1, David Chitty1, Meeyoung Lee1

  • 1Northwell Health Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra, Feinstein Institute for Medical Research, Lake Success, NY, USA.

Journal of Cellular Signaling
|July 2, 2020
PubMed
Summary
This summary is machine-generated.

Numerous clinical trials are underway to find effective COVID-19 treatments. This research summarizes ongoing studies, including those for cancer patients, offering hope for timely interventions against the novel coronavirus.

Keywords:
BCGCOVID-19Convalescent plasmaCytokine stormImmunomodulatoryImmunosuppressionSARS-CoV-2Vaccines

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Area of Science:

  • * COVID-19 research
  • * Clinical trial analysis

Background:

  • * The COVID-19 pandemic necessitated urgent clinical trials to evaluate treatments.
  • * Over 650 studies were registered globally, with results emerging rapidly.

Purpose of the Study:

  • * To summarize national and international clinical trials for COVID-19.
  • * To highlight pivotal trials, including those in the oncology population.

Main Methods:

  • * Searched NCI website and Medline for clinical trial data.
  • * Summarized 284 actively recruiting studies for confirmed COVID-19 cases.
  • * Categorized trials into drug therapies, immunomodulators, plasma, and vaccines.

Main Results:

  • * 284 studies actively recruiting, spanning early to late phases (I-IV).
  • * Trials focus on antivirals, cytokine storm modulators, convalescent plasma, and vaccines.
  • * Includes trials for adult and pediatric populations, and oncology patients.

Conclusions:

  • * Ongoing research aims for timely and effective COVID-19 treatments.
  • * Acknowledges the critical contributions of research teams and volunteers.