Related Experiment Video

Updated: Jul 4, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.2K

Risk Factors for Mortality in Patients with COVID-19 in New York City

Takahisa Mikami1,2, Hirotaka Miyashita1,2, Takayuki Yamada1,2

  • 1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Journal of General Internal Medicine
|July 2, 2020
PubMed

Insights

Older age, male sex, and certain clinical indicators like low oxygen saturation increase COVID-19 mortality risk. Hydroxychloroquine use was linked to decreased mortality in this large New York City patient study.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Clinical Medicine

Background:

  • New York City became a major epicenter for the COVID-19 pandemic.
  • Understanding clinical characteristics and mortality risk factors is crucial.

Purpose of the Study:

  • To identify clinical characteristics and risk factors for mortality in a large COVID-19 patient population in the USA.
  • To analyze outcomes in patients treated in the New York City metropolitan area.

Main Methods:

  • A retrospective cohort study was conducted.
  • Data from 6493 laboratory-confirmed COVID-19 patients were analyzed.
  • Clinical outcomes and mortality were tracked from March 13 to April 17, 2020.

Main Results:

  • The overall in-hospital mortality rate was 13.2% (858/6493).
  • Factors associated with increased mortality included older age (>50 years), hypotension, tachypnea, hypoxia, impaired renal function, elevated IL-6, D-dimer, and troponin.
  • Female sex, African American race, and hydroxychloroquine use were associated with decreased mortality.

Conclusions:

  • Older age, male sex, hypotension, tachypnea, hypoxia, impaired renal function, and elevated biomarkers (D-dimer, troponin) are significant risk factors for in-hospital mortality in COVID-19 patients.
  • Hydroxychloroquine use showed a protective association, reducing in-hospital mortality.
Abstract

More Related Videos

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.3K
In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model06:40

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

Published on: November 17, 2018

11.5K

Related Concept Videos

Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...