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Updated: Dec 16, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.3K
Progress to Date in Advancing Stratified Medicine in Psoriasis
Claire Reid1,2, Lis Cordingley3, Richard B Warren4,5
1Centre for Dermatology Research, NIHR Manchester Biomedical Research Centre University of Manchester, Manchester, UK. claire.reid@manchester.ac.uk.
American Journal of Clinical Dermatology
|July 2, 2020
Summary
Stratified medicine for psoriasis faces challenges due to disease complexity. Understanding psoriasis natural history, including genetic and environmental factors, is key to personalized patient care and earlier intervention.
Area of Science:
- Dermatology and immunology, focusing on complex inflammatory skin diseases.
Background:
- Psoriasis is a complex skin condition with varied presentations and comorbidities.
- Stratified medicine aims to tailor treatments to individual patient characteristics.
- Current biologic therapies for psoriasis are effective but not universally successful, with limited access.
Purpose of the Study:
- To explore the challenges and future directions in applying stratified medicine to psoriasis care.
- To highlight the importance of understanding psoriasis natural history for personalized treatment approaches.
Main Methods:
- Review of current understanding of psoriasis immunology and therapy response.
- Analysis of emerging patient subpopulations based on clinical and pharmacogenomic factors.
- Discussion of the interplay between genetic, inflammatory, and environmental factors in disease progression.
Main Results:
- Significant progress in understanding psoriasis immunology has led to targeted therapies.
- Distinct patient subpopulations show varied responses to biologic treatments.
- The natural history of psoriasis, including onset, progression, and comorbidity development, remains incompletely understood.
Conclusions:
- A deeper understanding of psoriasis natural history is crucial for advancing stratified medicine.
- Personalized patient care in psoriasis requires integrating genetic, inflammatory, and environmental insights.
- Earlier intervention strategies are essential for improving psoriasis management outcomes.
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