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Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation
Published on: January 20, 2018
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Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers
Jessica Wagner1, Marcel Dillenburger, Johanna Simon
1Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany. muellen@mpip-mainz.mpg.de weil@mpip-mainz.mpg.de.
Abstract:
Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches.

