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Methodological Issues in Population-Based Studies of Multigenerational Associations.
American Journal of Epidemiology
|July 2, 2020
Summary
Investigating multigenerational effects in human populations presents challenges for epidemiology. This study explores study designs and analysis strategies to accurately assess exposure associations across generations.
Area of Science:
- Epidemiology
- Human Population Studies
- Multigenerational Research
Background:
- Animal research indicates exposures can have multigenerational effects, impacting descendants.
- Epidemiology aims to study these multigenerational effects in human populations.
- Population-based studies face challenges due to lack of laboratory control.
Purpose of the Study:
- To describe methodological challenges in human multigenerational studies.
- To outline taxonomy for study designs and exposure associations.
- To identify strategies for recovering target associations.
Main Methods:
- Review of current strategies using birth registries and cohort studies.
- Description of methodological issues, including study design and analysis.
- Simulation study to evaluate different multigenerational designs.
Main Results:
- Different multigenerational designs yield varying estimates of exposure associations.
- Target associations can be recovered using auxiliary information.
- Insights provided for selecting appropriate target associations.
Conclusions:
- Methodological rigor is crucial for accurate multigenerational studies in humans.
- Careful consideration of study design and analysis is needed.
- Further methodological development is required in this field.
Keywords:
clustered dataendocrine disruptorsenvironmental exposureepidemiologic methodsmaternal exposuremultigenerational associationsstudy designMore Related Videos
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