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Updated: Dec 16, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
[Endogenous endophtalmitis in a patient withStaphylococcus aureusbacteraemia]
J H van den Besselaar1,2, J S Chua3, R van der Pol4
1Alrijne Ziekenhuis, afd. Interne geneeskunde, Leiden.
Staphylococcus aureus bacteraemia can lead to serious complications like endophthalmitis, causing vision loss. Prompt recognition and intraocular antibiotic treatment can restore vision.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Internal Medicine
Background:
- Staphylococcus aureus bacteraemia poses a risk for metastatic infections, including endocarditis, spondylodiscitis, and prosthetic joint infections.
- Endogenous endophthalmitis is a severe complication of S. aureus bacteraemia, potentially leading to irreversible vision loss.
- Standard treatment for endophthalmitis involves intraocular antibiotic injections or vitrectomy.
Observation:
- A 79-year-old male presented with septic arthritis and confirmed S. aureus bacteraemia.
- The patient developed blurred vision on the second day of admission, diagnosed as endophthalmitis.
- He was transferred to an academic hospital for specialized treatment.
Findings:
- The patient received intraocular antibiotic therapy for S. aureus endophthalmitis.
- Following treatment, the patient experienced significant improvement in his vision.
Implications:
- Patients with S. aureus bacteraemia presenting with visual complaints require urgent evaluation.
- Early infectious disease consultation is crucial for timely diagnosis and management of endophthalmitis.
- Referral to specialized centers for intraocular antibiotic administration is essential for managing suspected endophthalmitis.
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