Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis.

M Lohoff¹, C Matzner, M Röllinghoff

¹Institut für Klinische Mikrobiologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.

Infection and Immunity

|August 1, 1988

Summary

T cells are essential for the polyclonal B-cell stimulation observed in mice infected with Leishmania major. Specific T cells directly trigger B cells, leading to proliferation and immunoglobulin production, confirming T-cell dependency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PD-1 checkpoint blockade in patients with relapsed AML after allogeneic stem cell transplantation.

Bone marrow transplantation·2016

Same author

Fracture risk of vertebral bodies after cryosurgery using a miniature cryoprobe: A biomechanical in-vitro analysis on human bones.

Technology and health care : official journal of the European Society for Engineering and Medicine·2016

Same author

Lymphokines and monokines in the clinic.

Immunology today·2014

Same author

IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.

Cell death and differentiation·2014

Same author

[Complication analysis of spinal interventions in adult central movement disorders and scoliosis].

Zeitschrift fur Orthopadie und Unfallchirurgie·2013

Same author

Broth microdilution protocol for minimum inhibitory concentration (MIC) determinations of the intracellular salmonid pathogen Piscirickettsia salmonis to florfenicol and oxytetracycline.

Journal of fish diseases·2013

Area of Science:

Immunology
Infectious Diseases
Parasitology

Background:

Leishmania major infection in mice causes polyclonal B-cell stimulation in lymphoid organs.
This stimulation has been hypothesized to be T-cell dependent.

Purpose of the Study:

To provide experimental evidence for the role of T cells in Leishmania major-induced polyclonal B-cell stimulation.

Main Methods:

Utilized BALB/c-derived, L3T4-positive T cells specific for Leishmania major.
Co-cultured these T cells with syngeneic B cells.

Main Results:

Demonstrated that Leishmania major-specific T cells induce polyclonal proliferation in syngeneic B cells.
Observed immunoglobulin production by the stimulated B cells.

Related Experiment Videos

Conclusions:

Confirmed that T cells are crucial for the polyclonal B-cell response during Leishmania major infection.
Showcased the direct inductive capacity of specific T cells on B-cell activation and antibody production.