[Assessment of endogenous intoxication values by oral fluid composition]

Area of Science:

• Biochemistry
• Toxicology
• Oral Medicine

Background:

• Acute drug poisoning is a significant health concern.
• Endogenous intoxication can arise as a complication of drug toxicity.
• Oral mucosa changes, such as catarrhal stomatitis, may occur following drug poisoning.

Purpose of the Study:

• To investigate endogenous intoxication markers in oral fluid of patients with drug-induced catarrhal stomatitis.
• To quantify levels of substances of low and medium molecular weight (SLMMW) in oral fluid.
• To correlate SLMMW levels with the presence and severity of catarrhal stomatitis post-drug poisoning.

Main Methods:

• Saliva samples were collected from 20 patients with acute drug poisoning and 10 healthy controls.
• Patients were categorized into those with and without oral mucosa pathology.
• Concentrations of SLMMW in oral fluid were measured to assess intoxication levels.

Main Results:

• Patients with acute drug poisoning exhibited a 15.3% statistically significant increase in SLMMW compared to healthy individuals.
• Oral fluid from patients with drug-induced stomatitis showed a 42.3% elevation in total SLMMW levels.
• These findings indicate a clear link between drug poisoning, endogenous intoxication, and oral mucosal changes.

Conclusions:

• Endogenous intoxication is detectable in oral fluid following acute drug poisoning.
• Catarrhal stomatitis developing after drug poisoning is associated with elevated SLMMW.
• Regular oral cavity monitoring is recommended for patients with acute drug poisoning to detect and manage mucosal pathologies promptly.