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Epigenetic targeting in lymphoma.

Stephen Booth1, Graham Collins2

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British Journal of Haematology
|July 2, 2020
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Epigenetic alterations are crucial in lymphoma development. This review covers epigenetic modifying agents for lymphoma, examining their efficacy and ongoing clinical trials for relapsed or refractory cases.

Keywords:
clinical trialsepigeneticslymphoid malignancies

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Area of Science:

  • Hematology
  • Oncology
  • Epigenetics

Background:

  • Lymphoid malignancies, including lymphomas, present a significant clinical challenge, particularly in relapsed or refractory settings.
  • Despite treatment advances, patient prognosis in these advanced stages often remains poor.
  • Epigenetic alterations are increasingly recognized as key drivers in the pathogenesis of lymphoid cancers.

Purpose of the Study:

  • To review the critical role of epigenetic modifications in lymphoma biology.
  • To summarize the clinical experience with epigenetic modifying agents across different lymphoma subtypes.
  • To discuss current and future clinical studies involving these agents for lymphoma treatment.

Main Methods:

  • Literature review of published studies on epigenetic alterations in lymphoma.
  • Analysis of clinical trial data for epigenetic modifying agents in various lymphoma subtypes.
  • Synthesis of information on ongoing clinical investigations.

Main Results:

  • Epigenetic modifications are integral to the development and progression of lymphomas.
  • Epigenetic modifying agents have shown variable efficacy in clinical studies, dependent on lymphoma subtype.
  • Several ongoing clinical trials are evaluating novel epigenetic therapies for lymphoma.

Conclusions:

  • Epigenetic modifications represent a promising therapeutic target in lymphoid malignancies.
  • Further research and clinical trials are essential to optimize the use of epigenetic agents in lymphoma treatment.
  • Targeting epigenetic alterations offers potential for improved outcomes in relapsed or refractory lymphoma patients.