Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and the severity of pulmonary failure.

J A Weigelt1, D E Chenoweth, K R Borman

  • 1Department of Surgery, University of Texas Health Science Center, Dallas 75235.

The Journal of Trauma
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and efficacy of erythropoietin in traumatic brain injury patients: a pilot randomized trial.

Critical care research and practice·2010
Same author

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost.

Diabetologia·2010
Same author

In vitro evaluation of the antibacterial activity of three different central venous catheters against gram-positive bacteria.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2002
Same author

Mesenteric ischemia: an unusual presentation of traumatic intrahepatic arterioportal fistula.

The American surgeon·2001
Same author

An objective analysis of process errors in trauma resuscitations.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2000
Same author

It's time to sweat the little things.

Archives of surgery (Chicago, Ill. : 1960)·2000

Elevated complement levels, specifically C3a and C5a, correlate with the severity of lung damage in patients at risk for adult respiratory distress syndrome (ARDS). Early detection using these markers aids in defining ARDS risk.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Critical Care

Background:

  • Complement-induced granulocyte aggregation is a suspected cause of adult respiratory distress syndrome (ARDS).
  • Quantifying lung damage in ARDS patients is challenging.
  • Complement levels and oxygenation parameters may help define pulmonary deterioration severity.

Purpose of the Study:

  • To investigate the correlation between complement activation levels (C3a and C5a) and the severity of pulmonary insult in high-risk patients.
  • To determine if complement levels can aid in the early identification of patients at risk for ARDS.

Main Methods:

  • Forty-five high-risk patients were selected based on arterial blood gas criteria.
  • Patients were stratified into pulmonary dysfunction and ARDS categories based on shunt, oxygen gradient, and radiographic findings.

Related Experiment Videos

  • Complement levels (C3a and C5a) were measured over a 96-hour monitoring period and compared between severity groups.

    • Main Results:

    • ARDS patients exhibited significantly higher C3a and C5a levels compared to patients with pulmonary dysfunction.
    • The amount of complement activation correlated with the severity of the eventual pulmonary insult.
    • Arterial blood gases combined with C3a and C5a levels showed potential for earlier ARDS risk definition.

    Conclusions:

    • Complement activation, measured by C3a and C5a, is a significant indicator of pulmonary insult severity in high-risk patients.
    • These complement markers, alongside arterial blood gases, can facilitate earlier and more accurate identification of patients at risk for ARDS.
    • This study supports the use of complement levels as a biomarker for ARDS progression.