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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Dec 16, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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A framework for assessing glaucoma progression using structural and functional indices jointly.

Sampson Listowell Abu1, Iván Marín-Franch1,2, Lyne Racette1

  • 1Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

Plos One
|July 2, 2020
PubMed
Summary
This summary is machine-generated.

This study developed a framework to assess glaucoma progression by combining retinal nerve fiber layer thickness and visual field tests. This approach maintains specificity while improving detection rates for glaucoma.

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Area of Science:

  • Ophthalmology
  • Glaucoma research
  • Diagnostic methods

Background:

  • Glaucoma progression is typically identified using various tests and indices.
  • Combining multiple indices may reduce the specificity of glaucoma progression detection.
  • Accurate and specific methods are crucial for timely glaucoma management.

Purpose of the Study:

  • To develop a novel framework for assessing glaucoma progression.
  • To jointly utilize structural (retinal nerve fiber layer thickness) and functional (visual field sensitivity) indices.
  • To maintain a fixed specificity of 95% in glaucoma progression assessment.

Main Methods:

  • Included 337 eyes from 207 patients with ocular hypertension or primary open-angle glaucoma.
  • Utilized longitudinal data including retinal nerve fiber layer thickness (RNFLT) and static automated perimetry mean sensitivity (SAP MS).
  • Applied linear regression to assess index deterioration and derived joint criteria (ANY and ALL) at 95% specificity.

Main Results:

  • Retinal nerve fiber layer thickness (RNFLT) showed higher positive detection rates (15-45%) compared to SAP MS.
  • The joint ANY criterion yielded a 12% higher positive rate than the ALL criterion.
  • RNFLT alone showed comparable rates to the ANY criterion but uniquely identified a subset of progressing eyes.

Conclusions:

  • A simple framework for joint assessment of glaucoma progression using two indices was established.
  • The framework successfully maintains specificity while improving detection.
  • This approach is extensible to multiple parameters and novel predictive indices for glaucoma.