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Antioxidant cocktail following a high-sodium meal does not affect vascular function in young, healthy adult humans: a

Katarina Smiljanec1, Alexis U Mbakwe1, Macarena Ramos-Gonzalez1

  • 1Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE.

Nutrition Research (New York, N.Y.)
|July 2, 2020
PubMed

Insights

A high-sodium meal did not acutely impair vascular function in healthy young adults. Antioxidant cocktails were not necessary to mitigate any potential negative effects on blood pressure, arterial stiffness, or endothelial function.

Area of Science:

  • Cardiovascular physiology
  • Nutritional science
  • Oxidative stress research

Background:

  • Chronic high sodium intake is linked to cardiovascular disease by impairing vascular function via oxidative stress.
  • The acute impact of high-sodium meals on vascular health in young, healthy individuals requires further investigation.

Purpose of the Study:

  • To examine the acute effects of a high-sodium meal (HSM) on vascular function.
  • To determine if an antioxidant (AO) cocktail can mitigate any adverse vascular responses to an HSM.

Main Methods:

  • A randomized, crossover, blinded study involving healthy adults.
  • Participants consumed either an AO cocktail or placebo, followed by a high-sodium meal (1500 mg).
  • Vascular parameters including blood pressure, flow-mediated dilation (FMD), pulse wave velocity (PWV), and augmentation index (AIx) were measured over 120 minutes.

Main Results:

  • No significant differences in endothelial function (FMD), arterial stiffness (PWV), or wave reflection (AIx) were observed between the AO cocktail and placebo groups.
  • While mean blood pressure showed a slight increase over time, there was no significant difference between treatments.
  • A high-sodium meal did not acutely impair vascular function in this cohort.

Conclusions:

  • Young, healthy adults appear to tolerate the acute vascular effects of a high-sodium meal without significant impairment.
  • Antioxidant intervention is not necessary to counteract the acute vascular impact of a high-sodium meal in this population.

Keywords:
AntioxidantsHumansSaltSodiumVascular function

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