Related Experiment Video
Updated: Dec 16, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
An Overview of Contrast-Associated Acute Kidney Injury Following Lower-Extremity Percutaneous Peripheral
Tung H Nguyen, Omar Sheikh, Momhammed Sha'ar
1Interventional Cardiology and Vascular Medicine, Department of Medicine, Division of Cardiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7872, San Antonio, TX 78229-3900 USA. anandprasadmd@gmail.com.
Insights
Contrast-associated acute kidney injury (CA-AKI) is a risk after endovascular procedures. This review focuses on CA-AKI following percutaneous peripheral interventions and prevention strategies.
Area of Science:
- Nephrology
- Cardiology
- Radiology
Background:
- Contrast-associated acute kidney injury (CA-AKI) is a known complication of iodinated contrast media used in endovascular procedures.
- CA-AKI is linked to adverse outcomes and has been extensively studied after percutaneous coronary interventions (PCI).
- Limited research exists on CA-AKI specifically within the context of percutaneous peripheral interventions (PPI).
Purpose of the Study:
- To review current knowledge on CA-AKI following percutaneous peripheral interventions.
- To discuss the incidence and management differences between CA-AKI in PCI and PPI.
- To highlight available prevention strategies for CA-AKI in the setting of PPI.
Main Methods:
- Literature review of studies on contrast-associated acute kidney injury.
- Comparative analysis of CA-AKI in percutaneous coronary intervention versus percutaneous peripheral intervention.
- Synthesis of current understanding and prevention strategies for CA-AKI in PPI.
Main Results:
- CA-AKI is a significant concern in endovascular procedures, including PPI.
- Differences in patient populations and procedural characteristics may influence CA-AKI rates between PCI and PPI.
- Effective prevention strategies are crucial for mitigating CA-AKI risk in PPI.
Conclusions:
- Further research is needed to fully understand CA-AKI in percutaneous peripheral interventions.
- Implementing preventive measures is essential for improving patient outcomes after PPI.
- Addressing CA-AKI in PPI is critical for advancing endovascular care.
Abstract:
Contrast-associated acute kidney injury, resulting from the use of iodinated contrast media, is a well-known adverse event following endovascular procedures and is associated with poor prognosis when it happens. There is an abundance of literature studying acute kidney injury following percutaneous coronary interventions, with very few studies done in the setting of percutaneous peripheral intervention. Although both percutaneous coronary intervention and percutaneous peripheral intervention utilize iodinated contrast media, several differences exist that can affect the incidence and management of contrast-associated acute kidney injury. This article aims to review what we currently know about contrast-associated acute kidney injury and available prevention strategies, specifically following percutaneous peripheral interventions.
Related Concept Videos
Cardiac Catheterization I: Pre-Procedure Overview
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury III: Clinical Manifestations

