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The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale.
Lena Tschiderer1, Lisa Seekircher1, Gerhard Klingenschmid1
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Gerontology
|July 2, 2020
Summary
The Prospective Studies of Atherosclerosis (Proof-ATHERO) consortium aggregates data from 74 studies to understand atherosclerosis development. This large-scale meta-analysis aims to improve cardiovascular disease prediction and characterization.
Area of Science:
- Cardiovascular Research
- Epidemiology
- Medical Data Science
Background:
- Atherosclerosis is a core mechanism in cardiovascular diseases.
- Clinical tests like carotid intima-media thickness and ankle-brachial index assess atherosclerosis.
- Large-scale data aggregation is needed to understand atherosclerosis progression.
Purpose of the Study:
- To establish the Prospective Studies of Atherosclerosis (Proof-ATHERO) consortium.
- To collate individual-participant data on atherosclerosis measures, risk factors, and cardiovascular disease incidence.
- To leverage a large dataset for enhanced characterization, understanding, and prediction of atherosclerosis.
Main Methods:
- Individual-participant data meta-analysis of 74 contributing studies.
- Inclusion of studies with atherosclerosis measures, cardiovascular risk factors, and disease incidence.
- Data cleaning, harmonization, and analysis using pre-defined plans.
Main Results:
- The Proof-ATHERO consortium includes 106,846 participants from 25 countries.
- Over 830,619 person-years of follow-up, with 17,270 incident cardiovascular events recorded.
- Mean age at baseline was 59 years, with 50% female participants.
Conclusions:
- The Proof-ATHERO consortium provides a robust platform for atherosclerosis research.
- Large-scale data enables better understanding of atherosclerosis development and clinical consequences.
- This collaborative effort aims to improve prediction models for cardiovascular diseases.
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