Observation on Treatment of Drug Resistant Kala-azar Patients with Fungizone in Patna, Bihar

54 cases of drug resistant kala-azar patients, some cases were resistant to sodium stibogluconate, some to even single dose of ambisome and some to miltefosine came to us for treatment. All necessary investigations were done and splenic aspirations were positive for LD bodies. All these patients were treated with Fungizone at a dose of 1mg/kg body wt diluted with 5% glucose and given slowly in 4 hours. On the day 21st splenic aspiration was done and other necessary investigations were repeated. LD body was not found in any splenic aspirate except one case with HIV. Initially all the patients were divided into two groups, one group was fed adequate milk during their course of treatment and other group adequate amount of fish in their diet. The patients in both the groups were compared in the end. There was no difference between two groups regarding parasitological clearance. All the patients had parasitological cure except one patient with HIV. The weight of the patients improved in both groups. The patient with HIV needed 3 courses of anti kala-azar drug to become negative for parasites of kala-azar i.e LD body. That cases was given treatment for HIV also. The moment he became negative of kala-azar, he fled away.