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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Cu(I)-Catalyzed Three-Component Cyclization for the Construction of Functionalized Thiazoles

Yajun Wang1, Xiang Liu1, Baofu Zhu1

  • 1School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center, Guangdong Pharmaceutical University, Zhongshan 528458, P. R. of China.

The Journal of Organic Chemistry
|July 3, 2020
PubMed
Summary

A new copper(I)-catalyzed reaction efficiently synthesizes functionalized thiazoles from thioamides, ynals, and alcohols. This one-pot method offers a straightforward route to valuable aryl or heteroaryl-substituted thiazoles.

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