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Updated: Dec 16, 2025

Estimation of Telomeric Repeat-containing RNA from DNA/RNA Hybrid Complexes
Published on: December 5, 2025
A genome-wide and cotranscriptional suppressor of R loops
Jacob P Matson1, Lee Zou1,2
1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Abstract:
R loops arise from hybridization of RNA transcripts with template DNA during transcription. Unrepaired R loops lead to transcription-replication collisions, causing DNA damage and genomic instability. In this issue of Genes & Development, Pérez-Calero and colleagues (pp. 898-912) identify UAP56 as a cotranscriptional RNA-DNA helicase that unwinds R loops. They found that UAP56 helicase activity is required to remove R loops formed from different sources and prevent R-loop accumulation genome-wide at actively transcribed genes.
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