Two Mixed-ligand Coordination Polymers: Crystal Structures and Protective Effect on Ischemic Stroke by Increasing...

Area of Science:

• Materials Chemistry
• Coordination Polymers
• Medicinal Chemistry

Background:

• Mixed-ligand coordination polymers offer tunable properties for various applications.
• Ischemic stroke remains a leading cause of death and disability worldwide.
• Developing novel therapeutic agents for neuroprotection is crucial.

Purpose of the Study:

• To synthesize and characterize two new mixed-ligand coordination polymers using flexible bis-imidazole ligands.
• To evaluate the neuroprotective effects of these compounds in a mouse model of ischemic stroke.
• To investigate the compounds' impact on glucagon-like peptide 1 receptor expression and cognitive function.

Main Methods:

• Solvothermal synthesis of coordination polymers {[Co(bbi)(tdc)]·5H2O}n and {[Cu2(bimb)(H2O)(μ3-tdc)2(DMF)2]·H2O}n.
• Structural characterization using single crystal X-ray diffraction (SXRD), elemental analysis, PXRD, TGA, and IR spectroscopy.
• In vivo evaluation using real-time reverse transcription-polymerase chain reaction (RT-PCR) and the Morris Water Maze experiment.

Main Results:

• Two novel coordination polymers were successfully synthesized and structurally elucidated.
• Compounds 1 and 2 demonstrated protective effects on cerebrovascular endothelial cells.
• Treatment with compounds 1 and 2 modulated glucagon-like peptide 1 receptor expression and improved cognitive function in mice.

Conclusions:

• The synthesized coordination polymers exhibit potential as therapeutic agents for ischemic stroke.
• Further research into their mechanism of action and clinical efficacy is warranted.
• These findings highlight the interdisciplinary potential of coordination chemistry in addressing critical health challenges.