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Simple rapid stabilization method through citric acid modification for magnetite nanoparticles.

Mohammed Ali Dheyab1,2, Azlan Abdul Aziz3,4, Mahmood S Jameel5,6

  • 1Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia. mohammed@student.usm.my.

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Summary
This summary is machine-generated.

Citric acid-functionalized iron oxide nanoparticles (Fe3O4@CA) were rapidly synthesized for enhanced stability. These magnetic nanoparticles show potential for biomedical applications due to their improved dispersion and properties.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Bare iron oxide nanoparticles (Fe3O4 NPs) often exhibit low stability and hydrophilicity, limiting their practical applications.
  • Surface functionalization is crucial for overcoming the limitations of bare Fe3O4 NPs.

Purpose of the Study:

  • To synthesize a stable and magnetized citric acid (CA)-functionalized iron oxide aqueous colloidal solution (Fe3O4@CA).
  • To develop a rapid and efficient method for producing functionalized magnetic nanoparticles.

Main Methods:

  • A one-step co-precipitation reaction at 65°C using Fe3+ and Fe2+ in a NaOH solution.
  • Surface functionalization of Fe3O4 nanoparticles with citric acid (CA) within 25 minutes.
  • Characterization using X-ray diffraction, transmission electron microscopy, Zeta potential, Fourier transform infrared spectroscopy, and vibrating sample magnetometry.

Main Results:

  • Successfully synthesized 19 nm-sized Fe3O4 NPs coated with CA (Fe3O4@CA).
  • Achieved a stabilized, homogeneous, and well-dispersed aqueous colloidal solution.
  • Demonstrated increased Zeta potential from -31 to -45 mV, indicating enhanced stability.
  • Obtained high magnetic saturation of 54.8 emu/g.

Conclusions:

  • Citric acid functionalization effectively enhances the stability and dispersibility of iron oxide nanoparticles in aqueous solutions.
  • The rapid, low-temperature synthesis method provides a viable route for producing Fe3O4@CA nanoparticles.
  • The synthesized Fe3O4@CA nanoparticles exhibit promising properties for diverse biomedical applications.