Related Experiment Video
Updated: Dec 16, 2025
09:02
Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform
Published on: November 10, 2016
10.7K
Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive
Farhad Ghanizadeh Gerayeli1, Farnaz Hosseini1, Zohreh Bagheri2
1Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
International Journal of Analytical Chemistry
|July 3, 2020
Summary
A novel sensor using silver nanoparticles and β-cyclodextrin was developed for detecting zidovudine (ZDV), an HIV antiviral drug. This method offers sensitive and selective ZDV determination in pharmaceutical formulations.
Area of Science:
- Nanotechnology
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Zidovudine (ZDV) is a crucial reverse transcriptase inhibitor for HIV treatment.
- Silver nanoparticles (AgNPs) are effective due to their molecular bonding capabilities for detecting various agents, including pharmaceuticals.
- Developing sensitive and selective methods for drug determination is vital in pharmaceutical analysis.
Purpose of the Study:
- To synthesize AgNP-modified β-cyclodextrin (β-CD) using green synthesis.
- To develop a sensitive and selective sensor for ZDV determination.
- To characterize the synthesized nanomaterial and validate its performance.
Main Methods:
- Green synthesis of AgNP-modified β-CD.
- Characterization using IR, UV-Vis, TEM, and XRD.
- Spectrophotometric determination of ZDV based on color change and absorption shifts.
Main Results:
- Characterization confirmed the successful synthesis of AgNP-modified β-CD.
- A distinct color change from yellow to red was observed in the presence of ZDV.
- The sensor demonstrated sensitive ZDV detection in the range of 50-500 μM with a detection limit of 42 μM.
- The sensor achieved good recovery rates when applied to ZDV determination in tablets.
Conclusions:
- AgNP-modified β-CD synthesized via green methods provides a sensitive and selective platform for ZDV detection.
- The developed sensor shows potential for practical application in pharmaceutical quality control.
- This approach offers a cost-effective and efficient method for analyzing ZDV in drug formulations.
