Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Region-specific Transcriptomic Signatures in Alzheimer's Disease: A Meta-analysis of Vulnerable Brain Regions Reveals MicroRNA-hub Gene Regulatory Networks.

Journal of medical signals and sensors·2026
Same author

Design and evaluation of a novel fusion antigen for diagnosing human strongyloidiasis: An immunoinformatics approach.

PloS one·2026
Same author

Target-specific daunorubicin nanoplatform based on anti-CD22-ScFv decorated β-cyclodextrin metal organic frameworks.

Therapeutic delivery·2026
Same author

Dissecting Uricase Immunogenicity: Unveiling the Role of Quaternary Epitopes through In Silico Analysis : Quaternary Epitope Insights in Uricase Immunogenicity.

Galen medical journal·2026
Same author

SARS-CoV-2 RNA in Follicular Fluid, Granulosa Cells, and Oocytes of COVID-19 Infected Women Applying for Assisted Reproductive Technology : SARS-CoV-2 Detection in Follicular Fluid.

Galen medical journal·2026
Same author

Machine Learning Application in Enhancing HIV Management and Treatment Outcomes: Revolutionizing HIV Infection.

Current HIV research·2026

Related Experiment Video

Updated: Dec 16, 2025

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform
09:02

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform

Published on: November 10, 2016

10.7K

Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive

Farhad Ghanizadeh Gerayeli1, Farnaz Hosseini1, Zohreh Bagheri2

  • 1Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

International Journal of Analytical Chemistry
|July 3, 2020
PubMed
Summary

A novel sensor using silver nanoparticles and β-cyclodextrin was developed for detecting zidovudine (ZDV), an HIV antiviral drug. This method offers sensitive and selective ZDV determination in pharmaceutical formulations.

More Related Videos

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

10.7K
Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds
10:10

Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds

Published on: November 13, 2021

9.2K

Related Experiment Videos

Last Updated: Dec 16, 2025

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform
09:02

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform

Published on: November 10, 2016

10.7K
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

10.7K
Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds
10:10

Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds

Published on: November 13, 2021

9.2K

Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Pharmaceutical Analysis

Background:

  • Zidovudine (ZDV) is a crucial reverse transcriptase inhibitor for HIV treatment.
  • Silver nanoparticles (AgNPs) are effective due to their molecular bonding capabilities for detecting various agents, including pharmaceuticals.
  • Developing sensitive and selective methods for drug determination is vital in pharmaceutical analysis.

Purpose of the Study:

  • To synthesize AgNP-modified β-cyclodextrin (β-CD) using green synthesis.
  • To develop a sensitive and selective sensor for ZDV determination.
  • To characterize the synthesized nanomaterial and validate its performance.

Main Methods:

  • Green synthesis of AgNP-modified β-CD.
  • Characterization using IR, UV-Vis, TEM, and XRD.
  • Spectrophotometric determination of ZDV based on color change and absorption shifts.

Main Results:

  • Characterization confirmed the successful synthesis of AgNP-modified β-CD.
  • A distinct color change from yellow to red was observed in the presence of ZDV.
  • The sensor demonstrated sensitive ZDV detection in the range of 50-500 μM with a detection limit of 42 μM.
  • The sensor achieved good recovery rates when applied to ZDV determination in tablets.

Conclusions:

  • AgNP-modified β-CD synthesized via green methods provides a sensitive and selective platform for ZDV detection.
  • The developed sensor shows potential for practical application in pharmaceutical quality control.
  • This approach offers a cost-effective and efficient method for analyzing ZDV in drug formulations.