Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin 2 increases protection against experimental rabies.

P Perrin1, M L Joffret, C Leclerc

  • 1Unité de la Rage, Institut Pasteur, Paris, France.

Immunobiology
|May 1, 1988
PubMed
Summary

Rabies vaccination stimulates interleukin 2 (IL 2) production, enhancing vaccine efficacy in mice. However, IL 2 alone showed limited protection in hamsters post-rabies virus infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to "Medicoeconomic study of microsurgical head and neck reconstructions" Eur. Ann. Otorhinolaryngol. Head Neck Dis. 128 (2011) 121-126.

European annals of otorhinolaryngology, head and neck diseases·2024
Same author

Corticospinal and spinal excitability during peripheral or central cooling in humans.

Journal of thermal biology·2023
Same author

[Screening for diabetic retinopathy in the Centre-Val de Loire region: A study based on the French national healthcare database].

Journal francais d'ophtalmologie·2020
Same author

[A preliminary survey on the interest of eating probiotics, cypress and echinacea to prevent the apparition of winter infections].

Phytotherapie (Paris, France)·2020
Same author

Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2018
Same author

Outbreak of trichinellosis in the Midi-Pyrénées region of France January - March 1998.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2017

Area of Science:

  • Immunology
  • Virology
  • Vaccinology

Background:

  • Rabies virus infection and vaccination elicit distinct immune responses.
  • Interleukin 2 (IL 2) is a key cytokine in immune regulation and response.
  • Understanding IL 2's role in rabies immunity is crucial for vaccine development.

Purpose of the Study:

  • To investigate the effect of rabies vaccination and infection on IL 2 production.
  • To evaluate the adjuvant potential of exogenous IL 2 in rabies vaccines.
  • To assess the therapeutic efficacy of IL 2 as a standalone treatment post-rabies virus exposure.

Main Methods:

  • In vitro stimulation of mouse splenocytes with rabies antigens after vaccination or infection.
  • In vivo administration of IL 2 with rabies vaccines in pre-exposure potency tests (NIH test) in mice.

Related Experiment Videos

  • In vivo administration of IL 2 with rabies vaccines in post-exposure potency tests in hamsters, followed by challenge with wild rabies virus.
  • Evaluation of IL 2's protective effect when administered alone post-infection in hamsters.

    • Main Results:

    • Whole inactivated rabies virus or immunosome vaccination induced high IL 2 production in vitro, unlike live rabies virus infection.
    • Exogenous IL 2 demonstrated an adjuvant effect, enhancing rabies vaccine potency in mice (pre-exposure).
    • IL 2 did not show an adjuvant effect in hamsters when used with a rabies vaccine in a post-exposure setting.
    • IL 2 alone protected 30-50% of infected hamsters when administered at specific time points post-infection.

    Conclusions:

    • Rabies vaccination, but not live infection, primes for specific IL 2 production.
    • IL 2 can enhance rabies vaccine efficacy in a pre-exposure model in mice.
    • IL 2 exhibits limited therapeutic potential as a standalone agent in a post-exposure model in hamsters, despite some protection observed.