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The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in
Marilena Kampa1, George Notas1, Efstathios N Stathopoulos2
1Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklon, Greece.
Abstract:
Tumor necrosis factor (TNF) superfamily consists of 19 ligands and 29 receptors and is related to multiple cellular events from proliferation and differentiation to apoptosis and tumor reduction. In this review, we overview the whole system, and we focus on A proliferation-inducing ligand (APRIL, TNFSF13) and B cell-activating factor (BAFF, TNFSF13B) and their receptors transmembrane activator and Ca2+ modulator (CAML) interactor (TACI, TNFRSF13B), B cell maturation antigen (BCMA, TNFRSF17), and BAFF receptor (BAFFR, TNFRSF13C). We explore their role in cancer and novel biological therapies introduced for multiple myeloma and further focus on breast cancer, in which the modulation of this system seems to be of potential interest, as a novel therapeutic target. Finally, we discuss some precautions which should be taken into consideration, while targeting the APRIL-BAFF system.
Insights
The Tumor Necrosis Factor (TNF) superfamily, particularly APRIL and BAFF, plays a role in cancer. Targeting this system offers potential therapeutic strategies for multiple myeloma and breast cancer.
Area of Science:
- Immunology
- Oncology
Background:
- The Tumor Necrosis Factor (TNF) superfamily encompasses 19 ligands and 29 receptors involved in critical cellular processes.
- This system regulates proliferation, differentiation, apoptosis, and tumor reduction.
Purpose of the Study:
- To review the TNF superfamily, focusing on APRIL and BAFF and their receptors.
- To explore their roles in cancer, specifically multiple myeloma and breast cancer.
- To discuss novel biological therapies and therapeutic targeting strategies.
Main Methods:
- Literature review of the TNF superfamily, APRIL, BAFF, and their receptors.
- Analysis of their involvement in cancer pathogenesis.
- Evaluation of current and potential therapeutic interventions.
Main Results:
- APRIL (A proliferation-inducing ligand) and BAFF (B cell-activating factor) are key members of the TNF superfamily.
- Their receptors include TACI, BCMA, and BAFFR.
- The APRIL-BAFF system is implicated in multiple myeloma and shows potential as a therapeutic target in breast cancer.
Conclusions:
- The APRIL-BAFF system represents a significant area for novel biological therapies in oncology.
- Targeting this system requires careful consideration of potential precautions.
- Further research into modulating this pathway may yield new treatments for various cancers.
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