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Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab

Kévin Chemello1, Sandra Beeské2, Thi Thu Trang Tran2

  • 1Laboratoire Inserm UMR 1188 DéTROI, Université de La Réunion, Sainte Clotilde, France.

JACC. Basic to Translational Science
|July 3, 2020
PubMed

Keywords:
3D, 3-dimensionalAU, arbitrary unitBSA, bovine serum albuminELISA, enzyme-linked immunosorbent assayFCR, fractional catabolic rateFRG, Fah(−/−)Rag2(−/−)Il2rg(−/−)HoFH, homozygous familial hypercholesterolemiaLC-MS/MS, liquid chromatography tandem mass spectrometryLDL, low-density lipoproteinLDL-C, low-density lipoprotein cholesterolLDLR, low-density lipoprotein receptorLp(a), lipoprotein(a)MFI, mean fluorescence intensityPBMC, peripheral blood mononuclear cellPBS, phosphate-buffered salinePCSK9, proprotein convertase subtilisin/kexin type 9apoB100, apolipoprotein B100bodipy, boron dipyrromethenelipoprotein(a)liver-humanized micelow-density lipoprotein receptorproprotein convertase subtilisin/kexin type 9rPCSK9, recombinant proprotein convertase subtilisin/kexin type 9

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