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Published on: December 19, 2020
Massive Pulmonary Thromboembolism in Patients with COVID-19; Report of Three Cases
Mehdi Pishgahi1, Zahra Ansari Aval2, Behzad Hajimoradi3
1Cardiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Severe COVID-19 cases can lead to pulmonary thromboembolism (PTE). Early anticoagulant prophylaxis with low-molecular-weight heparin (LMWH) is recommended for intensive care unit (ICU) patients to improve outcomes.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Cardiology
Background:
- COVID-19 presents diverse clinical manifestations, with coagulopathies and thromboembolic events increasingly recognized as critical factors.
- Understanding the link between severe COVID-19 and thrombotic complications is crucial for patient management.
Observation:
- Three intensive care unit (ICU) patients with severe COVID-19 developed massive pulmonary thromboembolism (PTE) shortly after disease onset.
- One patient experienced a fatal outcome, while two were successfully treated with thrombectomy and antithrombotic agents, respectively.
Findings:
- Severe COVID-19 is associated with a significant risk of developing massive pulmonary thromboembolism (PTE).
- Prompt medical intervention, including thrombectomy and antithrombotic therapy, can be effective in managing PTE in COVID-19 patients.
Implications:
- Physicians should proactively consider and plan for anticoagulant prophylaxis, particularly using low-molecular-weight heparin (LMWH), in severe COVID-19 cases.
- Early recognition and management of PTE are essential for improving prognosis in critically ill COVID-19 patients.
Abstract:
COVID-19 is a novel infectious disease, which has challenged people all around the world. As of today, healthcare practitioners and researchers have made great effort to understand the characteristics and clinical presentations of the disease; however, the existing literature is still incomplete in this regard. A growing body of evidence indicates that coagulopathies and thromboembolic events are of utmost importance in COVID-19 patients and are related to poor prognosis. Here, we report three ICU admitted cases of COVID-19, in which massive pulmonary thromboembolism (PTE) occurred a few days after disease onset. Unfortunately, one of the patients did not survive and two were treated; one with thrombectomy and other with antithrombotic agents. It seems that severe cases of COVID-19 are at risk for developing PTE and in-charge physicians should be prepared and plan for anticoagulant prophylaxis using low-molecular-weight heparin (LMWH).
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Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumonia III: Complications and Assessment

