[Machine perfusion for conditioning liver and kidneys before transplantation].

Area of Science:

• Transplantation Medicine
• Medical Devices
• Organ Preservation

Background:

• Machine perfusion is emerging as a critical technology in solid organ transplantation.
• The increasing use of marginal organs presents challenges in transplantation.
• Current transplantation practices face logistical hurdles, including working hour restrictions.

Purpose of the Study:

• To explore the role of machine perfusion in the future of solid organ transplantation.
• To highlight the benefits of machine perfusion for conditioning and viability testing of organs.
• To discuss how machine perfusion can improve the safety and predictability of organ transplants.

Main Methods:

• Investigating various machine perfusion algorithms for different organs.
• Utilizing hypothermic and normothermic perfusion sequences for organ conditioning.
• Evaluating the efficacy of machine perfusion in improving outcomes for marginal organs.

Main Results:

• Machine perfusion demonstrates significant benefits for conditioning marginal organs prior to transplantation.
• The addition of hypothermic and normothermic perfusion allows for the conditioning and viability assessment of damaged organs.
• Machine perfusion enhances recipient safety and facilitates more planned, daytime transplant procedures.

Conclusions:

• Machine perfusion is expected to become the standard of care in solid organ transplantation.
• This technology offers a solution for utilizing more marginal organs and improving transplant outcomes.
• Machine perfusion enhances safety, enables better organ assessment, and supports more efficient surgical scheduling.