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Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Published on: October 14, 2019

Multifocal Small Bowel Neuroendocrine Tumours.

Janice L Pasieka¹

¹Department of Surgery, Sections General Surgery and Surgical Oncology, Cumming School of Medicine, University of Calgary, North Tower FMC, 1403 29th Street NW, Calgary, Alberta, T2N 2T9, Canada. Janice.pasieka@ahs.ca.

World Journal of Surgery

|July 3, 2020

Summary

Multifocal tumors (MFT) in small bowel neuroendocrine tumors (SBNET) occur in up to 50% of cases. Despite challenges, MFTs do not appear to worsen patient prognosis, though long-term surveillance is crucial.

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Area of Science:

Oncology
Gastroenterology
Surgical Pathology

Background:

Multifocal tumors (MFT) are observed in up to 50% of small bowel neuroendocrine tumors (SBNET) cases.
Familial SBNET cases exhibit a higher MFT incidence, reaching 80%.

Purpose of the Study:

To explore the etiology and implications of multifocal disease in SBNET.
To clarify the prognostic significance of MFT in SBNET.
To address surgical challenges and surveillance strategies for MFT in SBNET.

Main Methods:

Review of contemporary surgical series and recent data on SBNET.
Analysis of tumor characteristics, including multifocality.
Evaluation of prognostic factors and long-term outcomes.

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Main Results:

The etiology of MFT in SBNET is multifactorial, potentially involving local metastases, genetic mutations (familial forms), or combined genetic/epigenetic factors.
Recent data indicate that MFT in SBNET is not associated with a poorer prognosis, contrary to historical observations.

Conclusions:

Multifocal disease in SBNET presents diagnostic and therapeutic challenges for surgeons.
While MFTs may not negatively impact prognosis, careful long-term surveillance is essential for managing these tumors.