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High-resolution peripheral quantitative computed tomography in children with osteogenesis imperfecta.

David J Fennimore1, Maria Digby1, Margaret Paggiosi2

  • 1Academic Unit of Child Health, University of Sheffield, Damer Street, Sheffield, S10 2TH, UK.

Pediatric Radiology
|July 3, 2020
PubMed
Summary

High-resolution peripheral quantitative CT is a feasible method for assessing bone health in children with osteogenesis imperfecta (OI) aged 9 and older. This advanced imaging technique offers a non-invasive way to evaluate bone structure in pediatric patients with OI.

Keywords:
Bone mechanical propertiesBone microstructureChildrenDual-energy X-ray absorptiometryFeasibility studyHigh-resolution peripheral quantitative computed tomographyOsteogenesis imperfecta

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Area of Science:

  • Pediatric Radiology
  • Orthopedics
  • Biomedical Engineering

Background:

  • Current methods like radiographs and DXA for monitoring bone health in children with osteogenesis imperfecta (OI) have limitations.
  • Osteogenesis imperfecta (OI) involves fragile, deformed bones, making imaging and positioning challenging in pediatric patients.
  • High-resolution peripheral quantitative CT (HR-pQCT) offers non-invasive bone microarchitectural data, a potential advancement in OI assessment.

Purpose of the Study:

  • To assess the feasibility of using high-resolution peripheral quantitative CT (HR-pQCT) in children with osteogenesis imperfecta (OI).
  • To compare HR-pQCT results with dual-energy X-ray absorptiometry (DXA) and healthy controls in pediatric OI patients.
  • To determine the minimum age for successful HR-pQCT scanning in children with OI.

Main Methods:

  • Feasibility study involving nine children aged 9-15 years with osteogenesis imperfecta (OI).
  • Utilized high-resolution peripheral quantitative CT (HR-pQCT) for bone microarchitectural assessment.
  • Compared HR-pQCT data with dual-energy X-ray absorptiometry (DXA) and data from healthy pediatric controls.

Main Results:

  • All nine recruited children with osteogenesis imperfecta (OI) were successfully scanned using HR-pQCT.
  • No patient preference was observed between HR-pQCT and dual-energy X-ray absorptiometry (DXA) modalities.
  • The study demonstrated successful HR-pQCT scanning in children with OI as young as 9 years old.

Conclusions:

  • High-resolution peripheral quantitative CT (HR-pQCT) is a feasible imaging technique for children with osteogenesis imperfecta (OI) aged 9 years and older.
  • HR-pQCT provides a non-invasive method to assess bone microarchitecture in pediatric OI patients.
  • Further research is needed to explore the clinical implications of HR-pQCT in managing pediatric osteogenesis imperfecta (OI).