Related Experiment Video

Updated: Dec 16, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.9K

MicroRNAs in the anticancer effects of celecoxib: A systematic review

Mohammad Amir Mishan1, Mohammad Amin Khazeei Tabari2, Mehryar Zargari3

  • 1Ocular Tissue Engineering Research Center, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

European Journal of Pharmacology
|July 3, 2020
PubMed

Insights

Cyclooxygenase-2 (COX-2) drives cancer progression and metastasis. This review explores how the COX-2 inhibitor celecoxib, via microRNA (miRNA) regulation, offers therapeutic anticancer potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cyclooxygenase-2 (COX-2) is a key enzyme in inflammation with a significant role in cancer development.
  • COX-2 promotes tumorigenesis via epithelial-to-mesenchymal transition (EMT), proliferation, migration, invasion, and metastasis.
  • MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and are implicated in cancer as tumor suppressors or oncogenes.

Purpose of the Study:

  • To systematically review the tumorigenic role of COX-2 in various cancers.
  • To highlight the anticancer therapeutic effects of celecoxib, a selective COX-2 inhibitor.
  • To elucidate the involvement of miRNA regulation in COX-2-mediated cancer development and celecoxib's action.

Main Methods:

  • Systematic literature review.
  • Analysis of studies investigating COX-2, celecoxib, and miRNA interactions in cancer.
  • Synthesis of evidence on COX-2's tumorigenic mechanisms and celecoxib's therapeutic potential through miRNA modulation.

Main Results:

  • COX-2 significantly contributes to cancer progression and metastasis through various cellular mechanisms.
  • Celecoxib demonstrates anticancer potential by selectively inhibiting COX-2 and modulating downstream pathways.
  • Evidence indicates that COX-2 exerts its functions, in part, through the regulation of specific miRNAs.

Conclusions:

  • COX-2 plays a critical role in tumorigenesis and metastasis.
  • Celecoxib represents a promising therapeutic agent for cancer treatment by targeting COX-2 and influencing miRNA expression.
  • Targeting the COX-2-miRNA axis offers a novel strategy for cancer therapy.
Keywords:
COX-2CancerCelecoxibmiRNA

More Related Videos

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.8K
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

233

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.7K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.5K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.4K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
3.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K