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Development of a self-constrained 3D DenseNet model in automatic detection and segmentation of nasopharyngeal
Liangru Ke1, Yishu Deng2, Weixiong Xia3
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, PR China; Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, PR China.
Objectives:
We aimed to develop a dual-task model to detect and segment nasopharyngeal carcinoma (NPC) automatically in magnetic resource images (MRI) based on deep learning method, since the differential diagnosis of NPC and atypical benign hyperplasia was difficult and the radiotherapy target contouring of NPC was labor-intensive.
Materials And Methods:
A self-constrained 3D DenseNet (SC-DenseNet) architecture was improved using separated training and validation sets. A total of 4100 individuals were finally enrolled and split into the training, validation and test sets at a proximate ratio of 8:1:1 using simple randomization. The diagnostic metrics of the established model against experienced radiologists was compared in the test set. The dice similarity coefficient (DSC) of manual and model-defined tumor region was used to evaluate the efficacy of segmentation.
Results:
Totally, 3142 nasopharyngeal carcinoma (NPC) and 958 benign hyperplasia were included. The SC-DenseNet model showed encouraging performance in detecting NPC, attained a higher overall accuracy, sensitivity and specificity than those of the experienced radiologists (97.77% vs 95.87%, 99.68% vs 99.24% and 91.67% vs 85.21%, respectively). Moreover, the model also exhibited promising performance in automatic segmentation of tumor region in NPC, with an average DSC at 0.77 ± 0.07 in the test set.
Conclusions:
The SC-DenseNet model showed competence in automatic detection and segmentation of NPC in MRI, indicating the promising application value as an assistant tool in clinical practice, especially in screening project.
