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Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added

John Colombo1, Susan E Carlson2, Cecilia Algarín3

  • 1Schiefelbusch Institute for Life Span Studies and Department of Psychology, University of Kansas, Lawrence, KS, USA. colombo@ku.edu.

Pediatric Research
|July 3, 2020
PubMed

Insights

Prebiotics in infant formula improved daytime waking organization and reduced crying duration in infants. This suggests a positive influence on the gut-brain axis and supports actigraphy for sleep-wake pattern assessment.

Area of Science:

  • Pediatric Nutrition
  • Infant Development
  • Gut Microbiome Research

Background:

  • Limited research exists on the impact of prebiotics on infant behavior, physiology, and metabolism.
  • Understanding these effects is crucial for optimizing infant nutrition and development.

Purpose of the Study:

  • To investigate the effects of a prebiotic blend (polydextrose and galactooligosaccharides) on infant behavior, sleep-wake patterns, and gut microbiome.
  • To evaluate the efficacy of home-based actigraphy in assessing infant sleep-wake patterns.

Main Methods:

  • A double-blind randomized study involving 161 infants receiving either standard formula or formula with added prebiotics (PDX/GOS) from 14 to 112 days of age.
  • Infant behavior (crying/fussing, awake/content), 24-h sleep-wake actigraphy, salivary cortisol, and stool microbiome analysis were performed.
  • 131 infants completed the study.

Main Results:

  • Infants receiving PDX/GOS showed significantly shorter crying/fussing durations and longer nap latencies by 112 days of age.
  • Significant differences in stool microbiome diversity and taxa abundance were observed in the PDX/GOS group.
  • Cortisol awakening response was present in both groups.

Conclusions:

  • Prebiotics in infant formula promote faster consolidation of daytime waking states and reduce crying.
  • The findings support the use of home-based actigraphy for assessing infant sleep-wake patterns.
  • Prebiotic-induced changes in wake organization suggest a role for the gut-brain axis, warranting further research.
Abstract

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