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Updated: Dec 16, 2025

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
Published on: June 16, 2023
Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer
Keisuke Enomoto1, Muneki Hotomi1
1Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Abstract:
Thyroid cancer cells have a high amino acid demand for proliferation, invasion, and metastasis. Amino acids are taken up by thyroid cancer cells, both thyroid follicular cell and thyroid parafollicular cells (commonly called "C-cells"), via amino acid transporters. Amino acid transporters up-regulate in many cancers, and their expression level associate with clinical aggressiveness and prognosis. This is the review to discuss the therapeutic potential of amino acid transporters and as molecular targets in thyroid cancer.
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