Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

316
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
316
Compensation Mechanisms01:28

Compensation Mechanisms

1.8K
The human body employs intricate mechanisms to counteract changes in blood pH, preventing conditions like acidosis (pH < 7.35) and alkalosis (pH > 7.45). These compensatory responses aim to restore normal arterial blood pH by engaging respiratory or renal systems, depending on the source of the imbalance.
Respiratory Compensation
This mechanism addresses metabolic-induced pH imbalances by adjusting breathing rates. Respiratory compensation begins within minutes of detecting a pH...
1.8K
Decision Making: P-value Method01:09

Decision Making: P-value Method

6.7K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can...
6.7K
Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

2.1K
Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
2.1K
Incentive Theory: Pull Theory of Motivation01:18

Incentive Theory: Pull Theory of Motivation

775
Incentive theory, or the "pull theory" of motivation, suggests that external rewards primarily drive behavior. Individuals are motivated to engage in activities when they anticipate a desirable outcome. This is why people often work hard for promotions or study intensively to achieve high grades. These incentives can be tangible, physical rewards such as money or promotions, or intangible, non-physical rewards like praise and social recognition.
The theory differentiates between...
775
Bioequivalence Data: Statistical Interpretation01:16

Bioequivalence Data: Statistical Interpretation

123
Body:The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...
123

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Review of the Use of Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy in Pediatric Patients.

Cancers·2023
Same author

<i>In Situ</i> Study of Structure Formation under Stress in Stretchable Conducting Nanocomposites.

The journal of physical chemistry letters·2023
Same author

SARS-CoV-2 vaccination induced cerebral venous sinus thrombosis: Do megakaryocytes, platelets and lipid mediators make up the orchestra?

Free neuropathology·2023
Same author

The Role of Montelukast Sodium in Children with Adenoid Hypertrophy - A Comparative Study.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2023
Same author

AIE-active cyclometalated iridium(III) complexes for the detection of lipopolysaccharides and wash-free imaging of bacteria.

Dalton transactions (Cambridge, England : 2003)·2023
Same author

Comparison of Radiological and Clinical Outcomes between Expandable and Non-expandable Cages Following Cervical Corpectomy: A Systematic Review and Meta-analysis.

Asian spine journal·2023
Same journal

Regionalization of Mitral Transcatheter Edge-to-Edge Repair: Balancing Access and Expertise.

Circulation. Cardiovascular quality and outcomes·2025
Same journal

Making Your Blood Boil: Challenges and Opportunities for Using Emergency Department Data to Understand the Impact of Structural Inequities on Health.

Circulation. Cardiovascular quality and outcomes·2025
Same journal

Association Between Cardiac Rehabilitation and 1-Year Mortality by Frailty Level in Medicare Beneficiaries.

Circulation. Cardiovascular quality and outcomes·2025
Same journal

Association of Neighborhood Violent Crime With Hypertension-Related Emergency Department Visits in Chicago.

Circulation. Cardiovascular quality and outcomes·2025
Same journal

Improving Quality in Cardiac Arrest via Resuscitation Academy Training (IQ-CART): Study Protocol for a Mixed-Methods Study With a Focus on Low-Performing EMS Agencies.

Circulation. Cardiovascular quality and outcomes·2025
Same journal

From Referral to Recovery: Maximizing Enrollment and Participation in Cardiac Rehabilitation.

Circulation. Cardiovascular quality and outcomes·2025
See all related articles

Related Experiment Video

Updated: Dec 16, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.0K

Can Pay-for Performance Incentive Levels be Determined Using a Cost-Effectiveness Framework?

Ankur Pandya1,2, Djøra I Soeteman1, Ajay Gupta3

  • 1Center for Health Decision Science (A.P., D.I.S.), Harvard T.H.

Circulation. Cardiovascular Quality and Outcomes
|July 4, 2020
PubMed
Summary
This summary is machine-generated.

Pay-for-performance policies can determine cost-effective financial incentives for healthcare quality improvements. Simulation modeling for acute ischemic stroke care suggests a 10-minute reduction in treatment time is achievable with adjusted payments.

Keywords:
cost-benefit analysislife expectancypopulationquality improvementsquality-adjusted life year

More Related Videos

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

6.3K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

717

Related Experiment Videos

Last Updated: Dec 16, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.0K
Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

6.3K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

717

Area of Science:

  • Health economics
  • Healthcare policy
  • Simulation modeling

Background:

  • Pay-for-performance policies are increasingly used by US healthcare payers to link provider reimbursement to quality and value.
  • Cost-effectiveness analysis (CEA) is a tool to quantify healthcare value but is not yet integrated into designing or prioritizing pay-for-performance strategies.
  • Acute ischemic stroke care serves as a model to demonstrate how simulation can inform pay-for-performance incentive levels.

Purpose of the Study:

  • To develop a framework using simulation modeling to determine cost-effective financial incentives for pay-for-performance policies.
  • To apply this framework to acute ischemic stroke care to identify optimal incentive levels for improving quality metrics.

Main Methods:

  • Developed a simulation model to estimate quality-adjusted life years (QALYs) and costs associated with quality improvements.
  • Calculated incentive levels by back-calculating monetary values based on lifetime discounted QALYs and costs.
  • Applied the framework to an acute ischemic stroke microsimulation model comparing current Medicare policy with hypothetical pay-for-performance policies based on time-to-thrombolytic treatment with tPA.

Main Results:

  • Pay-for-performance policies incentivizing a 10-minute reduction in door-to-needle time for tPA treatment were found to achieve equivalent population-level net monetary benefit compared to current payment policies.
  • This 10-minute improvement could lead to an additional 5057 acute ischemic stroke cases treated within the optimal 0-3 hour window annually.
  • Incentive payments could range from 18% to 44% of current tPA payments, depending on the willingness-to-pay for health outcomes.

Conclusions:

  • Cost-effectiveness modeling can establish upper bounds for financial incentives in pay-for-performance policies, though data and modeling assumptions present limitations.
  • For acute ischemic stroke, financial incentives promoting a 10-minute decrease in door-to-needle time are recommended, with incentives not exceeding 18%–44% of current tPA payments.
  • Optimal incentive levels are contingent on willingness-to-pay, parameter uncertainty, and assumptions linking quality improvements to long-term health outcomes and costs.