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Complement C4B-null alleles in Felty's syndrome
W Thomson1, P A Sanders, M Davis
1University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, United Kingdom.
Arthritis and Rheumatism
|August 1, 1988
Abstract:
C4A and C4B allotypes were compared in 20 patients with Felty's syndrome (FS), 52 patients with rheumatoid arthritis (RA), and 55 control subjects. Nineteen of the FS patients had HLA-DR4. A C4B-null allele was more frequent in the patients with FS (60%) than in either the RA patients (15%) or the control subjects (26%). Only the differences between patients with FS and those with RA remained statistically significant when DR4 positive subjects were compared. The C4B null allele may identify individuals within the rheumatoid population who are at risk of developing particular systemic complications.