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CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation

Gilbert Aaron Lee1, Nan-Shih Liao2

  • 1Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|July 4, 2020
PubMed

The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

Keywords:
CD8(+)CD122(+) T cell homeostasisIL-15

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