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Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study

Anne Gedebjerg1,2, Mette Bjerre3, Alisa Devedzic Kjaergaard4

  • 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark aged@clin.au.dk.

Diabetes Care
|July 4, 2020
PubMed

Insights

Mannose-binding lectin (MBL) levels show a U-shaped association with cardiovascular events and mortality in type 2 diabetes patients. Both low and high MBL levels increase cardiovascular disease risk.

Area of Science:

  • Immunology
  • Cardiology
  • Endocrinology

Background:

  • Mannose-binding lectin (MBL) is implicated in cardiovascular disease (CVD) risk among diabetic individuals.
  • The precise nature of the association between MBL and CVD in type 2 diabetes remains unclear.

Purpose of the Study:

  • To investigate the relationship between serum MBL levels and MBL expression genotypes with cardiovascular events (CVE) and all-cause mortality in type 2 diabetes.
  • To clarify the role of MBL as a potential risk factor for CVD in this patient population.

Main Methods:

  • A cohort study involving 7,588 patients with type 2 diabetes.
  • Serum MBL levels and MBL expression genotypes were measured and categorized as low, intermediate, or high.
  • Cardiovascular events and all-cause mortality were tracked and analyzed using spline and Cox regression models.

Main Results:

  • A U-shaped association was observed between serum MBL levels and CVE risk. Low and high MBL levels were associated with increased CVE risk compared to intermediate levels (HRs 1.82 and 1.48, respectively).
  • A similar U-shaped association was found for all-cause mortality, though with lower risk estimates.
  • MBL expression genotype also showed a U-shaped association with CVE risk, with high-expression genotypes linked to increased risk (HR 1.44).

Conclusions:

  • Both serum MBL levels and MBL expression genotypes exhibit a U-shaped association with cardiovascular event risk in individuals with type 2 diabetes.
  • These findings suggest that MBL is a significant risk factor for cardiovascular disease in the diabetic population.
Abstract

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