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Hashimoto's thyroiditis might increase polycystic ovary syndrome and associated comorbidities risks in Asia
Chun-Wei Ho1, Hsin-Hung Chen1,2, Ming-Chia Hsieh1,3,4
1Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung.
Insights
Hashimoto's thyroiditis (HT) increases polycystic ovary syndrome (PCOS) risk by 2.37 times in Taiwanese women. Combined HT and PCOS significantly elevates coronary artery disease (CAD) risk by 5.92 times.
Area of Science:
- Endocrinology
- Reproductive Health
- Cardiovascular Health
Background:
- Hashimoto's thyroiditis (HT) and polycystic ovary syndrome (PCOS) are common endocrine disorders.
- Investigating the co-occurrence and associated risks of HT and PCOS is crucial for women's health.
- Comorbidities like coronary artery disease (CAD) may be linked to these conditions.
Purpose of the Study:
- To examine the association between Hashimoto's thyroiditis (HT) and the risk of polycystic ovary syndrome (PCOS).
- To evaluate the prevalence of comorbidities, specifically coronary artery disease (CAD), in women with HT and PCOS.
Main Methods:
- A cohort study involving 3,996 Taiwanese women diagnosed with HT between 2000-2012.
- Propensity score matching (1:2 ratio) was used to create matched case and control groups.
- Statistical analyses included Cox proportional hazard regression, logistic regression, and Kaplan-Meier analysis.
Main Results:
- The risk of developing PCOS was 2.37 times higher in women with HT compared to controls.
- Hypertension and hyperlipidemia were more prevalent in HT patients without PCOS.
- The adjusted odds ratio for CAD was significantly higher (5.92 times) in patients with both HT and PCOS.
Conclusions:
- Hashimoto's thyroiditis is associated with a 2.37-fold increased risk of polycystic ovary syndrome in Taiwanese women.
- The co-occurrence of HT and PCOS significantly elevates the risk of coronary artery disease.
- These findings highlight the importance of screening for PCOS in women with HT and monitoring for cardiovascular risks.
Background:
To investigate whether increased the comorbidities such as coronary artery disease (CAD) and risks between Hashimoto's thyroiditis (HT) and polycystic ovary syndrome (PCOS) in Taiwanese women.
Methods:
Patients newly diagnosed as having HT during 2000-2012 were assigned to the case group. Cases and controls were matched for age and comorbidities at a 1:2 ratio using propensity score matching. Incidence was calculated in the unit of 1000 person-year. Univariate and multivariate Cox proportional hazard regression, multivariate Cox, logistic regression, and Kaplan-Meier analyses were performed.
Results:
Among 3,996 participants, 2,664 constituted the control group and 1,332 constituted the case group. The PCOS risk in patients with HT increased by 2.37 times [95% confidence interval (CI): 1.22-4.62] compared with the controls. Hypertension (HTN) [adjusted odds ratio (OR): 1.31, 95% CI: 1.03-1.66] and hyperlipidemia (adjusted OR: 1.55, 95% CI: 1.2-1.9) were more common in HT patients without PCOS than in other patients. The adjusted OR for CAD in patients with HT was 1.51 (95% CI: 1.11-2.06), whereas that in patients with HT and PCOS was 5.92 (95% CI: 1.32-26.53).
Conclusions:
In our study, the PCOS risk in patients with HT increased by 2.37 times, which is lower than the increase in HT risk in Asian patients with PCOS (4.56 times). The proportion of CAD increased significantly by 5.92 times in patients with HT and PCOS compared with patients with HT only.
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