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Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19

Marina Rieder1,2, Isabella Goller3,4, Maren Jeserich3,4

  • 1Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. marina.baeuml@universitaets-herzzentrum.de.

Journal of Thrombosis and Thrombolysis
|July 4, 2020
PubMed

Insights

COVID-19 patients had a numerically higher rate of venous thromboembolism (VTE) compared to controls, though not statistically significant. D-dimer levels correlated with disease severity in COVID-19 patients.

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Cardiology

Background:

  • COVID-19 is linked to coagulopathy and venous thromboembolism (VTE).
  • Previous studies on COVID-19 coagulopathy often lacked control groups or focused solely on critically ill patients.
  • Understanding VTE risk in a broader COVID-19 patient population is crucial.

Purpose of the Study:

  • To determine the rate of VTE in an all-comers cohort with suspected COVID-19.
  • To investigate the association between D-dimer levels and disease course in COVID-19 patients.

Main Methods:

  • Prospective, single-center study of 190 patients with suspected COVID-19.
  • Patients were divided into SARS-CoV-2 positive (n=49) and negative (control, n=141) groups.
  • 30-day follow-up for VTE diagnosis and mortality assessment; D-dimer levels were monitored.

Main Results:

  • VTE occurred in 6.1% of SARS-CoV-2 positive patients versus 3.5% in controls (p=0.427).
  • 30-day mortality was similar between groups (6.1% vs. 5%, p=0.720).
  • Maximum D-dimer levels during follow-up correlated with disease severity in COVID-19, but admission levels did not.

Conclusions:

  • While not statistically significant, VTE rates were numerically higher in suspected COVID-19 patients compared to controls.
  • VTE events in the COVID-19 group were predominantly observed in intensive care unit (ICU) cases.
  • Elevated D-dimer levels during follow-up, not at admission, are associated with COVID-19 disease severity.

Keywords:
COVID-19D-dimersSARS-CoV-2Venous thromboembolism

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