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Related Experiment Video

Updated: Dec 16, 2025

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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The Gut-Eye Axis: Lessons Learned from Murine Models.

Jason L Floyd1, Maria B Grant2

  • 1Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Ophthalmology and Therapy
|July 4, 2020
PubMed
Summary

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Gut·2025

A disrupted gut microbiota (dysbiosis) may contribute to eye diseases like diabetic retinopathy and macular degeneration. Restoring gut health shows promise for preventing these conditions.

Area of Science:

  • Microbiome research
  • Ophthalmology
  • Immunology

Background:

  • A balanced gut microbiota is crucial for digestion and immune homeostasis.
  • Gut dysbiosis can trigger systemic inflammation, contributing to various diseases.
  • Emerging evidence links gut health to ocular pathologies.

Purpose of the Study:

  • To review evidence on the gut microbiota's role in ocular diseases.
  • To explore potential therapeutic strategies targeting gut dysbiosis for eye conditions.

Main Methods:

  • Literature review focusing on rodent studies.
  • Analysis of the connection between gut dysbiosis and specific eye diseases.
  • Examination of therapeutic interventions for gut microbiota restoration.
Keywords:
Age-related macular degenerationChoroidal neovascularizationDiabetic retinopathyDietFecal microbiota transplantGlaucomaGut microbiotaIntermittent fastingProbioticUveitis

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Last Updated: Dec 16, 2025

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Main Results:

  • Rodent studies suggest a link between gut dysbiosis and diabetic retinopathy, age-related macular degeneration, choroidal neovascularization, and uveitis.
  • Systemic inflammation driven by dysbiosis may exacerbate ocular pathologies.
  • Therapeutic approaches aimed at re-establishing gut eubiosis show potential.

Conclusions:

  • Gut microbiota dysbiosis is implicated in the development and progression of several major eye diseases.
  • Modulating the gut microbiota represents a promising avenue for novel therapeutic strategies in ophthalmology.