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Updated: Oct 9, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
Lipofibromatosis-Like Neural Tumor: A Case Report and Review of the Literature
Laura Crumbach1, Françoise Descotes2, Pierre-Paul Bringuier3
1Hospices Civils de Lyon, Hôpital Lyon Sud, Service d'anatomie et de cytologie pathologiques, Pierre Bénite, France.
Abstract:
Lipofibromatosis-like neural tumors (LPF-NT) are soft tissue tumors characterized by a lipofibromatosis-like pattern, CD34/PS100 positivity, and recurrent NTRK1 gene rearrangement. It occurs mainly in pediatric patients or young adults. We report here, the first case of LPF-NT in a middle-aged adult initially misdiagnosed as a myoepithelial tumor. LPF-NT may have a locally aggressive course but no recurrence was seen after complete surgeries, whereas metastatic diseases remain exceptional.

